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1. The thoracic CT shows interval worsening of pre-existing nodules and bibasilar peribronchial infiltration, ground-glass opacity, and bronchiectasis

The thoracic CT shows worsening of pre-existing nodules and bibasilar peribronchial infiltration, ground-glass opacity, and bronchiectasis. In particular, at least one nodule in the right upper lobe (see panels C-E, Figure 6) has shown enlargement. No clear evidence of upper lobe bronchiectasis, pleural effusions, or peribronchial / hilar and mediastinal lymph node enlargement is noted.

Clinical course: The patient subsequently underwent another repeat thoracic CT just over one month later (Figure 7), which suggested worsening of the basal peribronchial opacities, enlargement of the dominant right upper lobe nodule, and several new nodular opacities bilaterally.

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Figure 7. Repeat thoracic CT scan again showing worsening of the basal peribronchial opacities, enlargement of the dominant right upper lobe nodule, and several new nodular opacities bilaterally. Panels A-I: Static images in lung windows. Lower panel: Movie in lung windows.

Which of the following represents the most appropriate next step for the management of this patient? (Click on the correct answer to proceed to the next panel)

  1. 18FDG-PET scan
  2. 68Ga-citrate scanning
  3. Pulmonary function testing
  4. Repeat thoracic CT with intravenous contrast
  5. Ventilation-perfusion scanning

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