Correct!
2. Eosinophilic pneumonia

Pulmonary calcifications can occur in association with a broad spectrum of disease processes. Broadly speaking, pulmonary calcification can be divided into two categories: diffuse small calcifications and large or confluent calcifications. Diffuse small calcifications typically result from infectious processes such as histoplasmosis, tuberculosis, or healed varicella pneumonia. This pattern can also be seen with pneumoconiosis (such as silicosis), non-malignant metastatic calcification (from end stage renal disease or hyperparathyroidism), or genetic disorders such as pulmonary alveolar microlithiasis. Large or confluent nodular calcifications can result from malignant pulmonary metastasis, amyloidosis, or progressive massive fibrosis. Eosinophilic pneumonia is not one of the disorders classically associated with calcification (2).

Which of the following is most likely to be found on surgical lung biopsy? (Click on the correct answer to proceed to the next panel)

  1. Dendriform pulmonary ossification
  2. Hylainized pulmonary nodules with postively birefringent particles on polarized light microscopy
  3. Non-small cell adenocarcinoma
  4. Numerous calcified granulomas
  5. Small spherical, concentrically layered calcifications within alveoli

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