Correct!
4. Macrolide antibiotics

Macrolide antibiotics have a number of anti-inflammatory properties and have been used in multiple pulmonary inflammatory diseases (6). Recently, macrolides have been reported to help a patient with corticosteroid-refractory DIP. The patient was begun on daily therapy with clarithromycin and his FVC has improved from 51% to 68% predicted.

References

  1. Allen JN, Davis WB, Pacht ER. Diagnostic significance of increased bronchoalveolar lavage fluid eosinophils. Am Rev Respir Dis. 1990;142(3):642-7.
  2. Allen JN, Magro CM, King MA. The eosinophilic pneumonias. Semin Respir Crit Care Med. 2002;23(2):127-34.
  3. Kawabata Y, Takemura T, Hebisawa A, Ogura T, Yamaguchi T, Kuriyama T, Nagai S, Sakatani M, Chida K, Sakai F, Park J, Colby TV. Eosinophilia in bronchoalveolar lavage fluid and architectural destruction are features of desquamative interstitial pneumonia. Histopathology. 2008;52(2):194-202. doi: 10.1111/j.1365-2559.2007.02930.x.
  4. Guinee DG Jr. Pathology of eosinophilic pneumonia. Medscape. Available at: http://emedicine.medscape.com/article/2078412-overview#aw2aab6b6 (accessed 5/31/13).
  5. Ishiguro T, Takayanagi N, Kurashima K. et al. Desquamative interstitial pneumonia with a remarkable increase in the number of BAL eosinophils. Inter Med. 2008;47;779-84.
  6. Hoyt JC, Robbins RA. Macrolide antibiotics and pulmonary inflammation. FEMS Microbiol Lett. 2001;205:1-7.
  7. Knyazhitskiy A, Masson RG, Corkey R, Joiner J. Beneficial response to macrolide antibiotic in a patient with desquamative interstitial pneumonia refractory to corticosteroid therapy. Chest. 2008;134(1):185-7. doi: 10.1378/chest.07-2786.

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