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1. Lymphoma
The low power views show irregular fibroinflammatory nodules with central necrosis and an associated polymorphous cellular infiltrate consisting of small lymphocytes, histiocytes and plasma cells. Figure 3, panel D also shows some cells are Epstein-Barr virus positive.
Higher power views show large atypical cells including Reed-Sternberg cells against a background of lymphocytes. Reed–Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed–Sternberg cells are CD30 and CD15 positive.
The final pathology diagnosis was an atypical lymphohistiocytic infiltrate with necrosis best classified as EBV-positive immunodeficiency-associated lymphoproliferative disorder with Hodgkin lymphoma-like features.
What is the treatment for this type of lymphoma?