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4. 1 and 3
The patient is immunocompromised and hypoxemic so outpatient therapy is probably inappropriate (2). Furthermore, she is more likely to have organisms other than those seen with community-acquired pneumonia. Blood cultures are indicated in patients with pneumonia. She is admitted to the intensive care unit and blood cultures are obtained. Empiric antibiotic therapy is begun with piperacillin-tazobactam and levofloxacin. A bronchoscopy is planned for the next morning in the ICU with possible intubation. She remains relatively stable overnight on high flow oxygen. The technician is setting up for the bronchoscopy the next morning when a Gram-negative rod is reported growing in the blood cultures. Shortly afterward, the organism is tentatively identified as a Salmonella species.
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