Correct!
5. All of the above

Corticosteroids alone are inadequate for GPA. However, addition of a cytotoxic agent such as cyclophosphamide or methotrexate or a biologic agent such rituximab which is a monoclonal antibody against CD20, an antigen predominately on B cells result in high rates of remission. Our patient was treated with rituximab and corticosteroids and obtained complete remission.

References

1. Peachell MB, Müller NL. Pulmonary vasculitis. Semin Respir Crit Care Med. 2004 Oct;25(5):483-9. [CrossRef] [PubMed]
2. Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum. 1990 Aug;33(8):1101-7. [CrossRef] [PubMed]
3. Clain JM, Cartin-Ceba R, Fervenza FC, Specks U. Experience with rituximab in the treatment of antineutrophil cytoplasmic antibody associated vasculitis. Ther Adv Musculoskelet Dis. 2014 Apr;6(2):58-74. [CrossRef] [PubMed]

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